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AHK-Cu
Single Peptides
$49.99$0.50/mg
COA ON FILEMADE IN USA
Single Peptides
Thymosin Alpha 1
$59.99$6.00/mg
Description
Thymosin Alpha 1 is a synthetic, N-acetylated 28-amino-acid peptide. Supplied as a lyophilized powder in sealed vials. Each batch has its own certificate of analysis (COA), which opens when you scan the QR code on the label. For laboratory research use only. Not for human or veterinary use.
Research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease.
Research profile
Thymosin alpha-1 research profile
Thymosin alpha-1 is a 28-residue, N-terminally acetylated peptide first isolated from calf thymus by Allan Goldstein and colleagues in 1977. It is an N-terminal fragment of prothymosin alpha. Under the name thymalfasin it is the active ingredient of an approved medicine in a number of countries; it is not FDA-approved.
Specifications
- Sequence
- Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN-OH (28 residues)
- Molecular formula
- C129H215N33O55
- Molecular weight
- ≈ 3108.3 g/mol
- CAS number
- 62304-98-7
- Size
- 10 mg per vial
- Form
- Lyophilized powder, sealed vial
- Storage
- Keep sealed, protected from light and moisture; follow the label
- Testing
- HPLC purity and mass spectrometry identity, per lot. Scan the QR code on the vial for the certificate of analysis.
Published research
- Isolation and structure: Goldstein et al., PNAS, 1977; sequence analysis by Low et al., J Biol Chem, 1979.
- Dendritic cells and TLR signalling in a mouse Aspergillus transplant model (Romani et al., Blood, 2004).
- Recombinant production and N-acetylation in E. coli (Fang et al., 2009).
- Half-life extension by PASylation, studied in rats (Binder & Skerra, Int J Mol Sci, 2021).
Frequently asked questions
What is thymalfasin?
The international nonproprietary name for thymosin alpha-1 as a medicine, approved in a number of countries but not by the FDA.
What modification does thymosin alpha-1 carry?
An acetylated N-terminal serine; the C-terminus is a free acid.
How do I verify my lot?
Scan the QR code on the vial. It opens the certificate of analysis for that lot, with HPLC purity and the mass spectrometry identity result.
For laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. Literature references are provided for scientific context and do not describe this product's suitability for any use.
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